The global total – the fourth-highest ever – included $170.1m in the United States, a record for a March debut and the sixth-highest US opening weekend.
Dawn of Justice took £15.5m in the UK which is also a record for March.
The film bringing the two superheroes together for the first time is a welcome success for Warner Bros.
The studio has been hit by a series of expensive failures such as Jupiter Ascending and Pan in recent months.
The DC Comics adaptation, which cost more than $250m to make, was Warner Bros’ second-highest international opening after Harry Potter and the Deathly Hallows: Part 2.